New Publication in Immunity

"FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells"


Congratulations to Robin, Huipeng and Laurens!

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New Publication in Nature Communications

"Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation"

Congratulations to Lucie, Masahiro, Hannah, Snehlata, Robin and Teresa!

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New Publication in Nature

"Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation"

Congratulations to Huipeng, Laurens, Snehlata, Robin, Juan and Onur!

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New CRC 1403 "Cell Death in Immunity, Inflammation and Disease

CRC1403 focuses on cell death and its role in immunity and disease. Cell death is a fundamental biological process for multicellular organisms, traditionally viewed as a process safeguarding tissue homeostasis by counterbalancing cell proliferation. This view has dramatically changed during the last years by the identification of different genetically controlled cellular death programs and the realisation that these cell death pathways contribute to immunity and disease. Accumulating evidence revealed that dying cells communicate with bystander cells triggering tissue responses that could be protective by mediating tissue repair but could also cause tissue damage and disease. A new concept has now emerged, in which cell death is an integral component of the organismal response to stress caused by microbial and non-microbial insults that is important for both protective immunity and the pathogenesis of immune-related diseases. The overarching goal of the CRC 1403 is to explore how diverse forms of cell death are regulated and how they contribute to health and disease in animals and plants, with particular focus on immunity, inflammation and host-microbe interactions. The CRC1403 includes projects from scientists from the MNF and the Medical faculty of the UoC, together with scientists from the MPI for Plant Breeding Research and the MPI for Ageing Research and groups from the University of Bonn and the LMU in Munich. The CRC also provides a link between the Excellence Clusters CECAD and CEPLAS in Cologne as well as the EC Immunosensation in Bonn.


Spokesperson: Manolis Pasparakis

Deputy Spokesperson: Hamid Kashkar



New Publication in Nature Cell Biology

"A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain"

Congratulations to Apostolos and Onur!  

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