Mathilda Hahn joined our lab as a new technician.
Welcome!

"FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells"

Congratulations to Robin, Huipeng and Laurens!

Download the accepted manuscript here.

Fulltext link (publisher page): doi.org/10.1016/j.immuni.2020.04.002

Zhiyuan You joined our lab as a new postdoc.

Welcome!

Takashi Imai who was granted a fellowship by the TAKEDA Science Foundation, Japan joined our lab 

Welcome!

Nikos Oikonomou returned to our lab.

Welcome back!

Welcome!

CRC1403 focuses on cell death and its role in immunity and disease. Cell death is a fundamental biological process for multicellular organisms, traditionally viewed as a process safeguarding tissue homeostasis by counterbalancing cell proliferation. This view has dramatically changed during the last years by the identification of different genetically controlled cellular death programs and the realisation that these cell death pathways contribute to immunity and disease. Accumulating evidence revealed that dying cells communicate with bystander cells triggering tissue responses that could be protective by mediating tissue repair but could also cause tissue damage and disease. A new concept has now emerged, in which cell death is an integral component of the organismal response to stress caused by microbial and non-microbial insults that is important for both protective immunity and the pathogenesis of immune-related diseases. The overarching goal of the CRC 1403 is to explore how diverse forms of cell death are regulated and how they contribute to health and disease in animals and plants, with particular focus on immunity, inflammation and host-microbe interactions. The CRC1403 includes projects from scientists from the MNF and the Medical faculty of the UoC, together with scientists from the MPI for Plant Breeding Research and the MPI for Ageing Research and groups from the University of Bonn and the LMU in Munich. The CRC also provides a link between the Excellence Clusters CECAD and CEPLAS in Cologne as well as the EC Immunosensation in Bonn.

Contact:

Spokesperson: Manolis Pasparakis
E-Mail:pasparakis[at]uni-koeln.de

Deputy Spokesperson: Hamid Kashkar
E-Mail:h.kashkar[at]uni-koeln.de

"Temporally Distinct Functions of the Cytokines IL-12 and IL-23 Drive Chronic Colon Inflammation in Response to Intestinal Barrier Impairment"

Congratulations to Christina, Laurens and Robin!

Link:

https://www.sciencedirect.com/science/article/pii/S107476131930278X

Núria Sánchez-Coll and Manolis Pasparakis are happy to organize the EMBO Workshop on Cell death in immunity and inflammation, 06-09 October 2019, Crete, Greece.

For further information and registration, please click click the following link:  http://meetings.embo.org/event/19-cell-death

Tumay Telatar, Erasmus fellowship recipient, of the Middle East Technical University, Ankara joined our lab.

Welcome 

Announcing the Keystone Symposia Conference on “Skin Health and Disease: Immune, Epithelial and Microbiome Crosstalk”

Organized by Drs. Michel Gilliet of University Hospital of Lausanne, Emma Guttmanof Mount Sinai Hospital, Anthony Oro of Stanford University and Manolis Pasparakis of the University of Cologne, the three-day conference will:

• Present and discuss cutting-edge research on the role of the immune system, epithelial cells and skin microbiome, and crosstalk between these systems, with respect to skin health and its emerging importance in systemic health and disease defenses;
• Review the newest technologies and experimental approaches for treating and preventing skin diseases;
• Consider the future directions of the field, including the role immune-epithelial-microbiome crosstalk of the skin beyond the skin, in systemic diseases, and foster new collaborations among dermatologists, cancer biologists, immunologists, industrial researchers and other scientists.

For more information, please visit www.keystonesymposia.org/KS/Online/Events/Common/Past_Meeting.aspx

Christina Eftychi returned to our lab.

Welcome back!

Simone Wolf joined us as a new PhD-student.

 Welcome!