CECAD Microsite

Module Genetics MN-B-SM G 1 Cell Death in Inflammation, Immunity and Disease

Department of Mouse Genetics and Inflammation

Institute for Genetics/CECAD Cologne

 Prof. Manolis Pasparakis

together with the labs of

Prof. Dr. Hamid Kashkar

Institut für Medizinische Mikrobiologie, Immunologie und Hygiene


Dr. Silvia von Karstedt

Research Group „Cell Death and Cancer Evolution“/CECAD Cologne



Summer Term 2019 (20.05. -12.07.2019)


Module Description:

Click here for detailed course information


Please note:

The introduction to the module on 16 May 2019 at 1.00 pm will not take place in the seminar room 0.46 at the Institute for Genetics (ground floor) but in the adjacent lecture hall.

The course starts on Monday, 20  May at 9:15 am with a brief introduction and the obligatory safety instructions. Venue: seminar room 0.46 at the Institute for Genetics (ground floor) 

Reading List

  • Galluzzi, L. et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 1–56 (2018). doi:10.1038/s41418-017-0012-4
  • Broz P & Dixit VM (2016) Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol 16: 407–420
  • Hengartner MO (2000) The biochemistry of apoptosis. Nature 407: 770–776
  • Jorgensen I, Rayamajhi M & Miao EA (2017) Programmed cell death as a defence against infection. Nat Rev Immunol
  • Lamkanfi M & Dixit VM (2019) Manipulation of host cell death pathways during microbial infections. Cell Host Microbe. 8(1):44-54.
  • Oeckinghaus A & Ghosh S (2009) The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 1: a000034
  • Pasparakis M & Vandenabeele P (2015) Necroptosis and its role in inflammation. Nature 517: 311–320
  • Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H & Vandenabeele P (2014) Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol 15: 135–147
  • Varfolomeev E & Vucic D (2016) Intracellular regulation of TNF activity in health and disease. Cytokine
  • von Karstedt, S.*, Montinaro, A.*, and Walczak, H. (2017). Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy. Nat. Rev. Cancer 17, 352–366.
  • Yang WS & Stockwell BR (2016) Ferroptosis: Death by Lipid Peroxidation. Trends Cell Biol 26: 165–176
  • Proneth, B., and Conrad, M. (2018). Ferroptosis and necroinflammation, a yet poorly explored link. Cell Death Differ. 1–11



Contact and Coordination

Teresa Corona: tcorona[at]uni-koeln.de

Laurens Wachsmuth: wachsmul[at]uni-koeln.de