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Module Genetics MN-B-SM (A3) Cell Death in Inflammation, Immunity and Disease


Department of Mouse Genetics and Inflammation

Institute for Genetics/CECAD Cologne

 Prof. Manolis Pasparakis

together with the labs of


Prof. Dr. Hamid Kashkar

Institut für Medizinische Mikrobiologie, Immunologie und Hygiene

 and

Prof. Dr. Silvia von Karstedt

Research Group „Cell Death and Cancer Evolution“/CECAD Cologne

 

Summer Term 2021 (07.06. -23.07.2021)

Module Description:

Click here for detailed course information

Please note: The course starts on Monday, 7th of June at 9:15 am with a brief introduction and the obligatory safety instructions via ZOOM. Venue: Laboratory at the Institute for Genetics (Zülpicher Str. 47a, ground floor, room 0.24).  A Laptop for each student will be available. Please bring your own headset. The date for the Introduction to the module and a ZOOM link for lectures etc. will be sent to the participants via email. Reading List

  • Galluzzi, L. et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 1–56 (2018). doi:10.1038/s41418-017-0012-4
  • Broz P & Dixit VM (2016) Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol 16: 407–420
  • Hengartner MO (2000) The biochemistry of apoptosis. Nature 407: 770–776
  • Jorgensen I, Rayamajhi M & Miao EA (2017) Programmed cell death as a defence against infection. Nat Rev Immunol
  • Lamkanfi M & Dixit VM (2019) Manipulation of host cell death pathways during microbial infections. Cell Host Microbe. 8(1):44-54.
  • Oeckinghaus A & Ghosh S (2009) The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 1: a000034
  • Pasparakis M & Vandenabeele P (2015) Necroptosis and its role in inflammation. Nature 517: 311–320
  • Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H & Vandenabeele P (2014) Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol 15: 135–147
  • Varfolomeev E & Vucic D (2016) Intracellular regulation of TNF activity in health and disease. Cytokine
  • von Karstedt, S.*, Montinaro, A.*, and Walczak, H. (2017). Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy. Nat. Rev. Cancer 17, 352–366.
  • Yang WS & Stockwell BR (2016) Ferroptosis: Death by Lipid Peroxidation. Trends Cell Biol 26: 165–176
  • Proneth, B., and Conrad, M. (2018). Ferroptosis and necroinflammation, a yet poorly explored link. Cell Death Differ. 1–11

Contact and Coordination

Teresa Corona: tcorona[at]uni-koeln.de

Laurens Wachsmuth: wachsmul[at]uni-koeln.de